Search results for "32 Biomedical and Clinical Sciences"

showing 8 items of 8 documents

Biophysics of high density nanometer regions extracted from super-resolution single particle trajectories: application to voltage-gated calcium chann…

2019

AbstractThe cellular membrane is very heterogenous and enriched with high-density regions forming microdomains, as revealed by single particle tracking experiments. However the organization of these regions remain unexplained. We determine here the biophysical properties of these regions, when described as a basin of attraction. We develop two methods to recover the dynamics and local potential wells (field of force and boundary). The first method is based on the local density of points distribution of trajectories, which differs inside and outside the wells. The second method focuses on recovering the drift field that is convergent inside wells and uses the transient field to determine the…

0301 basic medicineField (physics)1.1 Normal biological development and functioningHigh densityBoundary (topology)lcsh:Medicine32 Biomedical and Clinical SciencesLocal field potentialArticleQuantitative Biology::Cell BehaviorQuantitative Biology::Subcellular ProcessesComputational biophysics03 medical and health sciences0302 clinical medicineSingle-molecule biophysics1 Underpinning researchlcsh:SciencePhysicsMultidisciplinary3208 Medical PhysiologyVoltage-dependent calcium channelFOS: Clinical medicinelcsh:RNeurosciencesScientific data030104 developmental biologyParticleNanometrelcsh:QBiological systemBiological physics51 Physical Sciences030217 neurology & neurosurgeryEnergy (signal processing)
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Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: An international consensus statement

2018

Beckwith-Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycaemia, lateralized overgrowth and predisposition to embryonal tumours. Delineation of the molecular defects within the imprinted 11p15.5 region can predict familial recurrence risks and the risk (and type) of embryonal tumour. Despite recent advances in knowledge, there is marked heterogeneity in clinical diagnostic criteria and care. As detailed in this Consensus Statement, an international consensus group agreed upon 72 recommendations for the clinical and molecular diagnosis and management …

0301 basic medicineBeckwith-Wiedemann SyndromeConsensusDNA Copy Number VariationsReproductive Techniques AssistedEndocrinology Diabetes and MetabolismLibrary science32 Biomedical and Clinical SciencesTranslational research030105 genetics & heredityPolymorphism Single NucleotideBildung03 medical and health sciencesRare DiseasesEndocrinologyPrenatal DiagnosisHumansMedicinemedia_common.cataloged_instancePediatric nephrologyChild growthEuropean union3202 Clinical Sciencesmedia_commonPediatricbusiness.industryEuropean researchExpert consensusDNA MethylationNeoplasms Germ Cell and EmbryonalNational health service3. Good healthMolecular Diagnostic Techniquesbusiness
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Protocol for the EARCO Registry

2020

Rationale and objectives Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that leads to an increased risk of emphysema and liver disease. Despite extensive investigation, there remain unanswered questions concerning the natural history, pathophysiology, genetics and the prognosis of the lung disease in association with AATD. The European Alpha-1 Clinical Research Collaboration (EARCO) is designed to bring together researchers from European countries and to create a standardised database for the follow-up of patients with AATD. Study design and population The EARCO Registry is a non-interventional, multicentre, pan-European, longitudinal observational cohort study enrolling patie…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyChronic Obstructive Pulmonary DiseasePopulation1MEDLINElcsh:Medicine61032 Biomedical and Clinical Sciences610 Medicine & health[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract03 medical and health sciencesLiver diseaseStudy Protocol0302 clinical medicineRare DiseasesClinical ResearchmedicineGenetics030212 general & internal medicineIntensive care medicineeducation3202 Clinical SciencesLungProtocol (science)Emphysemaeducation.field_of_studybusiness.industryPreventionlcsh:Rmedicine.disease3. Good healthNatural historyClinical research030228 respiratory systemObservational study10178 Clinic for PneumologybusinessCohort study
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The international WAO/EAACI guideline for the management of hereditary angioedema – the 2017 revision and update

2018

Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and appropriate therapy are essential. This update and revision of the global guideline for HAE provides up-to-date consensus recommendations for the management of HAE. In the development of this update and revision of the guideline, an international expert panel reviewed the existing evidence and developed 20 recommendations that were discussed, finalized and consented during the guideline consensus conference in June 2016 in Vienna. The final version of this update and revision of the guideline incorporates the contributions of a board of expert reviewers and the endorsing societies. The goal of this guideline up…

MaleAftercare32 Biomedical and Clinical SciencesLanadelumabC1-inhibitorDiseaseGuidelineRecommendations0302 clinical medicinePregnancyDiagnosisImmunology and Allergy030212 general & internal medicinePrecision MedicineChildHereditary angioedemaConsensus conferenceSelf-administrationManagementGRADEHereditary angioedemaFemaleComplement C1 Inhibitor ProteinQuality of lifeAdultPulmonary and Respiratory Medicinemedicine.medical_specialtyWhat treatmentConsensusAdolescentHealth Planning GuidelinesImmunologyMEDLINEDysfunctional family7.3 Management and decision makingYoung Adult03 medical and health sciencesRare DiseasesQuality of life (healthcare)Clinical ResearchTerminology as TopicIndividualized therapymedicineHumansLactationFinal versionProphylaxisbusiness.industryPreventionAngioedemas HereditaryGuidelinePrecision medicinemedicine.disease3211 Oncology and Carcinogenesis030228 respiratory systemFamily medicineTherapybusiness7 Management of diseases and conditions
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Immunosenescence and Cytomegalovirus

2010

Since Looney at al. published their seminal paper a decade ago [1] it has become clear that many of the differences in T cell immunological parameters observed between young and old people are related to the age-associated increasing prevalence of infection with the persistent β-herpesvirus HHV-5 (Cytomegalovirus). Ten years later, studies suggest that hallmark age-associated changes in peripheral blood T cell subset distribution may not occur at all in people who are not infected with this virus [[2]; Derhovanessian et al., in press]. Whether the observed changes are actually caused by CMV is an open question, but very similar, rapid changes observed in uninfected patients receiving CMV-in…

lcsh:Immunologic diseases. AllergyAgingCMV ImmunosenescenceageingT cellImmunologyCongenital cytomegalovirus infectionYellow fever vaccine32 Biomedical and Clinical Scienceslcsh:GeriatricsVirusImmune systemMedicine3202 Clinical Sciencesbiologybusiness.industryvirus diseasesImmunosenescenceBiological Sciencesmedicine.disease3204 Immunologylcsh:RC952-954.6Ageingmedicine.anatomical_structureImmunologyT cell subsetQR180biology.proteinCommentaryAntibodylcsh:RC581-607businessmedicine.drugImmunity & ageing
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CNN-Based Prostate Zonal Segmentation on T2-Weighted MR Images: A Cross-Dataset Study

2020

Prostate cancer is the most common cancer among US men. However, prostate imaging is still challenging despite the advances in multi-parametric magnetic resonance imaging (MRI), which provides both morphologic and functional information pertaining to the pathological regions. Along with whole prostate gland segmentation, distinguishing between the central gland (CG) and peripheral zone (PZ) can guide toward differential diagnosis, since the frequency and severity of tumors differ in these regions; however, their boundary is often weak and fuzzy. This work presents a preliminary study on deep learning to automatically delineate the CG and PZ, aiming at evaluating the generalization ability o…

Urologic DiseasesComputer scienceContext (language use)32 Biomedical and Clinical Sciences-Convolutional neural networkDeep convolutional neural networks Prostate zonal segmentation Cross-dataset generalizationProstate cancer46 Information and Computing SciencesProstateDeep convolutional neural networksmedicineAnatomical MRISegmentationProstate zonal segmentation; Prostate cancer; Anatomical MRI; Deep convolutional neural networks; Cross-dataset generalization;3202 Clinical SciencesCancerSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniProstate cancerSettore INF/01 - Informaticamedicine.diagnostic_testbusiness.industryDeep learningINF/01 - INFORMATICAMagnetic resonance imagingPattern recognitionmedicine.disease3211 Oncology and Carcinogenesismedicine.anatomical_structureCross-dataset generalizationProstate zonal segmentationBiomedical ImagingArtificial intelligenceDeep convolutional neural networkbusinessT2 weightedAnatomical MRI; Cross-dataset generalization; Deep convolutional neural networks; Prostate cancer; Prostate zonal segmentation
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Medicine of the future: How and who is going to treat us?

2023

Medicine’s ability to quickly respond to challenges raises questions from researchers, practitioners, and society as a whole. Our task in this study was to identify key and atypical current factors influencing the development of medicine and to predict the development of medicine in the short, medium, and long term. To implement our study, we selected 22 medical experts and applied the three-level Delphi method. The current trends caused by COVID-19 have a short-term impact, but they will launch other drivers that will transform the healthcare industry. Well-being technologies, data-informed personalization, and climate change will become key drivers for the development of medicine over the…

futuremedicineSociology and Political ScienceterveydenhuoltoforecasthealthcareGeneral Social SciencesGeneral Decision Sciencesennusteet32 Biomedical and Clinical Sciences3 Good Health and Well BeinglääketiedeDevelopmentDelphiGeneric health relevancetulevaisuusBusiness and International Management3202 Clinical Sciences48 Law and Legal StudiesFutures
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A phase I dose escalation and expansion study of the next generation oral SERD AZD9833 in women with ER-positive, HER2-negative advanced breast cancer

2020

1024 Background: AZD9833 is an oral selective estrogen receptor (ER) antagonist and degrader (SERD) that has shown antitumor efficacy in a range of preclinical models of breast cancer. Methods: SERENA-1 (NCT03616587) is an ongoing Phase 1, open-label study in pre- and post-menopausal women, after ≥1 endocrine therapy and ≤2 prior chemotherapies for ER+ HER2- advanced breast cancer (ABC). The primary objective is to determine the safety and tolerability of AZD9833 once daily (QD), with dose-limiting toxicities (DLTs) in 28d defining the maximum tolerated dose. Secondary objectives include pharmacokinetics and anti-tumor response. Pharmacodynamic (PD) analysis includes ER modulation in paire…

OncologyCancer Researchmedicine.medical_specialtyAdvanced breastClinical Trials and Supportive ActivitiesEstrogen receptor32 Biomedical and Clinical Sciences6 Evaluation of treatments and therapeutic interventions03 medical and health sciences0302 clinical medicineBreast cancerClinical ResearchInternal medicineBreast CancerDose escalationMedicineCancerbusiness.industryAntagonistHER2 negativeCancermedicine.disease3211 Oncology and CarcinogenesisOncology030220 oncology & carcinogenesis6.1 Pharmaceuticalsbusiness030215 immunology
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